As part of the revolutionary and fast-evolving field of immune rejuvenation, Sentcell LTD is seeking a highly motivated PhD student or Junior Postdoc (with a Felasa Certificate, if applicable) to explore molecular mechanisms and cutting-edge therapies focused on T cell and systemic rejuvenation. This research will take place in our newly established laboratory at Toscana Life Sciences, within the GSK Campus in Siena, Italy. The successful candidate will work at the forefront of cellular rejuvenation science, contributing to groundbreaking discoveries that have the potential to transform the treatment of age-related diseases and immune dysfunction. Nature Careers
Employer: Sentcell LTD
Location: Toscana Life Sciences, within the GSK Campus, Siena (Italy)
Salary: Competitive salary with bonuses and outstanding career growth opportunities
Closing Date: April 28, 2025
Required Expertise:
Candidates should have experience in some or all of the following laboratory techniques:
- Flow Cytometry
- In Vivo Studies
- Immunoblotting / Immunoprecipitation
- ELISA Assays
- PCR
- Primary Cell Cultures
🔹 Bioinformatics skills, particularly in docking predictions, are highly desirable.
Candidate Profile:
We are looking for individuals with a strong background in molecular and cellular biology, immunology, or related fields who are eager to push the boundaries of immune rejuvenation research.
Essential Qualifications & Skills:
- Master’s or PhD in Biology, Biotechnology, Medicine, or a related Life Science discipline
- PhD in progress or recently completed in Cellular/Molecular Biology, Molecular Medicine, or Immunology
- Felasa Certificate (for postdoctoral candidates)
- Strong communication skills in English (spoken and written)
- Ability to work effectively in a team-oriented environment
- Flexibility to travel between our Siena (GSK Campus) and London (University College London) laboratories
🔹 International research experience is preferred.
Candidates with expertise in immunology and/or biochemistry, particularly in signal transduction mechanisms, will be highly competitive for this role.
The Offer:
🌟 A highly competitive three-year contract aligned with experience and qualifications.
🌟 Significant salary growth and performance-based bonuses.
🌟 Unmatched career progression opportunities in a rapidly growing biotech company.
🌟 Exposure to groundbreaking research, from target discovery to clinical translation.
About Sentcell LTD:
Founded in 2019 by Prof. Dr. Alessio Lanna in the UK, Sentcell LTD has rapidly established itself as one of the leading biotech innovators in the field of immune rejuvenation.
Our work stems from the recognition that T lymphocytes, particularly CD4+ cells, are central to the aging process across all organs. However, despite their pivotal role, no T cell rejuvenation therapies currently exist—a gap that Sentcell is determined to fill.
🔬 Discover the “sMAC” macromolecular complex, the key driver of T cell aging (Lanna et al., Nature Immunology, 2014 & 2017).
🧬 Unveil a novel anti-aging mechanism involving telomere transfer via extracellular vesicles (Lanna et al., Nature Cell Biology, 2022).
💊 Develop the first-ever drug, “DOS,” capable of reversing T cell aging, remodeling the immune system, and driving systemic rejuvenation (Lanna et al., under consideration).
A Unique Opportunity to Be Part of Translational Innovation:
The first-in-human clinical trial of DOS is set to launch in the UK in 2025, offering an unparalleled research environment. Successful candidates will gain hands-on experience spanning target identification, drug discovery, and clinical translation, directly contributing to transformative medical advancements.
Join and be at the cutting edge of immune rejuvenation research, helping to shape the future of medicine.
🔹 Application Deadline: April 28, 2025
Sentcell LTD looks forward to welcoming passionate scientists eager to drive innovation in cellular rejuvenation and immune restoration.