Karolinska Institutet is one of the world’s leading medical universities, renowned for groundbreaking research and high-quality biomedical education. The Department of Laboratory Medicine conducts advanced basic, clinical, and epidemiological research across seven divisions, working closely with clinicians at the Karolinska University Hospital. The Division of Biomolecular and Cellular Medicine (BCM) focuses on therapeutic applications of modified biomolecules and cellular products. The research group (EL Andaloussi Lab) develops innovative technologies for safe and efficient delivery of macromolecules—such as RNA, proteins, and gene editors—to specific target tissues in vivo. Nature Careers
Employer: Karolinska Institutet (KI)
Department: Laboratory Medicine – Division of Biomolecular and Cellular Medicine (BCM)
Location: Huddinge (Flemingsberg), Sweden
Salary: Scholarship (Tax-Free Stipendium)
Application Deadline: 31 March 2026
Duration: Up to 2 years (within 4 years after PhD completion)
Research Focus
This postdoctoral project aims to develop novel bioconjugates for organ-targeted extrahepatic delivery of oligonucleotide therapeutics (e.g., ASOs, siRNAs). The lab explores:
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Engineering extracellular vesicles (EVs) as delivery vehicles
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Designing RNA conjugates using small ligands, nanobodies, or antibodies
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Understanding molecular determinants of tissue and cell tropism
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Evaluating biodistribution and delivery efficiency in vitro and in vivo
Key Responsibilities
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Design and optimize strategies for targeted oligonucleotide delivery
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Evaluate targeting ligands and conjugation chemistries
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Perform physicochemical characterization of RNA conjugates
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Conduct in vitro potency and delivery screening
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Assess biodistribution and activity in animal models
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Correlate molecular design with targeting efficiency
Eligibility Criteria
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PhD (or equivalent foreign degree) completed before the start date
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Applicants must be foreign researchers residing outside Sweden
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Scholarship duration: Maximum 2 years
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Strong background in oligonucleotide conjugate delivery and biodistribution studies
Required Expertise
In Vitro Characterization
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Physicochemical analysis of oligonucleotide conjugates
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Screening models for potency and delivery efficiency
Laboratory Animal Science
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Extensive mouse handling experience (IV, IP administration)
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Knowledge of ethics, animal welfare, and regulatory compliance
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Proven biodistribution evaluation in mouse models
Molecular & Cellular Biology
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Mammalian cell culture and transfection
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RT-qPCR, dPCR, SplintR, or related detection methods
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Strong experimental documentation and troubleshooting skills
Preferred (not mandatory):
Flow cytometry, RNA sequencing, toxicity studies, and in vivo imaging (IVIS).
What KI Offers
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A collaborative and internationally recognized research environment
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Cross-disciplinary medical research excellence
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Strong healthcare collaboration
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Access to modern gym facilities
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Tax-free scholarship paid biannually
Application Requirements
Submit via the Varbi recruitment system:
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Complete CV (including thesis details and academic record)
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Full publication list
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One-page summary of current research